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We therefore reasoned that the two apparent binding events could be attributed to a combination of the binding of one SAM to the S2 site and the resulting conformational rearrangement into the activated state

Three of the 12 evaluated compounds ( 64 , 65 , and 66 ) showed a promising response for further studies

Inhibitory effect of diacerein on diclofenac-induced acute nephrotoxicity in rats via modulating SIRT1/HIF-1/NF-B and SIRT1/p53 regulatory axes