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Ethics declarations Ethical approval and consent to participate This investigation was performed with strict adherence to the ethical guidelines laid out by our Ethical Committee and Institutional Review Board (Approval numberGU-IEC(NIV)/02/Proj/015)

In a study by Cohen et al[41] probability of avoiding colectomy at long-term follow-up (5.5 years) was 66% in patients receiving cyclosporin and azathioprine/mercaptopurine compared with 40% in those who received cyclosporin alone

Furthermore, the study by Sindi et al

The calculated binding affinities were 6.7 kcal mol 1 for R -THIQ in R2.2 and 7.6 kcal mol 1 for DHIQ in D2.1