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Somewhat contradictory to the observations in animals, Savage et al (56) reported 27 prepubertal children with severe GH insensitivity syndrome (GHIS or Severe Primary IGF Deficiency (SPIGFD)) to have a median (range) birth weight SDS of -0.72 (1.75 - (-3.29)) and birth length SDS of -1.59 (0.63 - (-3.63))

Indeed, inhibiting leukotriene signaling during MI has shown to impede excessive inflammation with reduced IL-1 expression, diminished leukocyte infiltration and to improve cardiac function in a murine model of MI [27]

If given too late (after cytokines already surged), the benefit wanes

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