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17 Compounding the issue is the fact that various professional organizations and grading references (the American Academy of Pediatrics, American Family Practice, Scottish Intercollegiate Guidelines Network, and many others) have different letter assignments and cutoffs for the use of non-RCT-containing literature, creating confusion about the meaning of an A, B, or C to denote the quality of literature used for evidence

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doi: 10.1016/j.molmed.2021.06.002 14 MuellerCLinJCSheriffSMaudsleyAAYoungerJW

Glutathione, however, is difficult to absorb orally and is best administered either via aerosol administration or intravenously thru IV