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In murine models, NNMT knockdown did not induce the accumulation of NAM in livers and adipose tissues, nor did it cause significant alterations in the intracellular levels of NAD + in hepatocytes (Kraus et al., 2014

Although both BacA and IcL groups displayed significant increases in CD4+ and CD4+CD45RO+ populations over time, only BacA induced an increase in the CD8+ population over time and a decrease in the FOXP3+ population at 14 weeks post-inoculation ( Figures 5E, F, H )