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Epigenetic modifications, particularly histone deacetylase (HDAC)-mediated chromatin remodeling, have emerged as a critical interface between chronic ethanol exposure and depressive phenotypes

The medication can also cause low blood pressure

Frederick et al., 2016), reduces the mitochondrial unfolded protein response (Mendelsohn and Larrick, 2017), disrupts ATP biosynthesis, decreases the ability to pump calcium against the intracellular gradient (Rzheshevsky, 2014) and has deleterious effects on muscle health (Goody and Henry, 2018)