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Exfoliation Glycolic Acid paired with natural Willow Bark gradually dissolves keratin buildup and clears plugged follicles, smoothing the skin's surface over time 2

doi:10.1080/09513590.2021.1974378

Microbiota metabolite butyrate differentially regulates Th1 and Th17 cells' differentiation and function in induction of colitis

Additionally, in 2D cultures, ECs can easily spread and migrate due to the lack of physical impediments, while in 3D cultures, a surrounding matrix poses constraints that enforce the ECs adaptation to fit through matrix pores and often require matrix degradation for spreading and migration [240]