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Likewise, activation of sirtuin-1 (SIRT1) by the compound F0911-7667 promotes PINK1-Parkin-mediated mitophagy to induce ACD, and the difference is that autophagy initiated by the former depends on the AKT-mTOR signaling pathway, whereas autophagy initiated by the latter depends on the AMPK-mTOR signaling pathway [13, 14]