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For the construction of reporter subnetwork, common metabolites, such as H 2 O, CO 2 , O 2 , H + , HCO 3 , Na + , CoA, P i , PP i , AMP, ADP, ATP, NAD + , NADH, NADP + , NADPH, PAP, PAPS, FAD and FADH 2 were removed as they associate with a multitude of metabolic pathways, and hence are not discriminative

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