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Schisandrin C improves leaky gut conditions in intestinal cell monolayer, organoid, and nematode models by increasing tight junction protein expression

Similar to ubiquitination, also SUMOylation occurs via a three-step cascade involving a single dimeric E1 enzyme, an E2 conjugating enzyme and E3 SUMO ligases attaching either SUMO1 or the highly related SUMO2/3 to the target