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showed that GPX3 was highly expressed in adipose tissue, and its expression was reduced in both the serum and adipose tissue of obese subjects, attributing this reduction to pro-oxidant conditions such as hypoxia and inflammation [140]

However, these modalities have demonstrated variable benefit and, due to inconsistent outcomes and tolerability constraints, have not achieved a consensus recommendation 26,32,33,34,35,36,37,38

the LPS-mediated effect, whereas low-dose CB+LPS did not

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