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Studies indicate that diminished VEGF expression precipitates neurodegeneration by compromising neural tissue perfusion, thus exacerbating neuronal vulnerability to ischemic insults and metabolic imbalances (Oosthuyse et al

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H 2 O 2 -induced cell death was also reproduced in primary neurons and was found to be attenuated by extracellular Ca 2+ removal with abolishing TRPM2 activation