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Yes loose skin, especially when that skin is weighed down by fat, can create health problems

Current gene therapy research aims to target, for example, upstream targets of the GSH system or molecules associated with it (such as Nrf2, GPX, SLC7A11), genes aberrantly expressed in myocardial injury, and noncoding RNAs regulating mRNA transcription [76, 202, 250,251,252,253]

Chronic stress activates sympathetic nervous system responses, elevates cortisol, and creates mental hyperarousal that interferes with sleep onset and maintenancewhile poor sleep quality impairs stress resilience, reduces emotional regulation capacity, and increases vulnerability to anxiety