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Pemetrexed is in a subcategory of antimetabolite drugs called folic acid analogs

Some individuals may start with weekly injections for a period and then transition to monthly injections for maintenance

If you've had a BAD experience with B12 shots, it's most likely that you do not tolerate or convert cyanocobalamin well (see if you can verify what form of B12 was in the shot that made you react poorly, and then stay away from that specific form if you can)