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When it comes to the gut, apigenin affects Enterococcus caccae cell wall/membrane synthesis and increases the incidence of protein misfolding Bacteroides galacturonicus growth was also inhibited by apigenin[and] apigenin promoted overall growth and diversity, lowered Firmicutes to Bacteroidetes ratio, and promoted production of short chain fatty acids, including butyrate, which is associated with health (Wang et al., 2017)

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Week 1 experiment: Administer DSIP 3 hours before intended sleep Track time to fall asleep, sleep quality, morning alertness Note any grogginess or sleep disturbance Week 2 experiment: Administer DSIP 1.5 hours before intended sleep Track the same variables Compare results to week 1 Week 3 experiment: Administer DSIP 30-45 minutes before intended sleep Track and compare Identify which timing produced the best results Some users find their optimal timing changes over a cycle