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A "disease-associated" gene or polynucleotide refers to any gene or polynucleotide which is yielding transcription or translation products at an abnormal level or in an abnormal form in cells derived from a disease-affected tissues compared with tissues or cells of a non disease control

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A pooled data analysis of 17 prospective studies showed a higher odds ratio for IGF-1 in ER positive breast cancer ( 2 induced phosphorylation of the IGF-1R and subsequent activation of ERK (Pandini et al., 2005)

Immunity 18 , 243253 (2003)