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In addition, the maintenance of body weight upon infection-associated cachexia in CD8 + T-cell null mice strongly suggest that CD8 + T-cells contribute to skeletal muscle wasting ( + CD44Low nave T-cells reduces muscle atrophy, muscle protein and DNA loss, even when inoculated after the onset of cachexia, associated with a protection from CD4 + T-cell lymphopenia (Wang et al., 2008)

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doi: 10.1038/s41467-022-30045-9 13

Jun 8 2021;doi:10.1016/j.cmet.2021.05.016 Ma YJ, Yu J, Xiao J, Cao BW