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Standard / Gradual Approach In the published animal work, dermorphin and its analogs were given in very small amounts by routes appropriate to a laboratory model : nanomole quantities injected directly into the lateral brain ventricle of rats, or on the order of micromoles per kilogram subcutaneously [3] [5]

Optional intermediate coating The solid oral pharmaceutical composition may further comprise one or more intermediate coatings located between the core and the first coating