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It is included here for completeness and because the mechanism, NF-B modulation and tight junction upregulation, overlaps with the compounds above in a way that is mechanistically interesting

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Piezo1 channels play a role in sensing mechanical properties in the microenvironment of neural progenitor cells, which allows the initiation of signaling pathways for neuronal differentiation and also determines the subsequent morphological structure of nerve fibers while altering the permeability of the glial membrane and activating its signaling pathways for nanosizing (Wu J