Secondary outcomes included: progression to Interstitial lung disease (ILD), rate of hospitalization
This factor was named CRF (Guillemin and Rosenberg, 1955)
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It contains rhein, emodin, aloe emodin, cassia, orange in of anthraquinones, and cassiaside, cassioside, cassia lactone of naphthopyrrolidones, and other sterols, fatty acids, sugars and proteins [31, 32]
