High Yield Bond Fund Fund Class 1 JPMorgan International Hedged Equity Fund - R6 JPMorgan International Hedged Equity Fund - R5 JPMorgan International Advantage Fund Class C Janus Henderson International Managed Volatility Fund - D Shares John Hancock Funds II Multi-Index Lifestyle Aggressive Portfolio Class 1 John Hancock Funds II Multi-Index Lifestyle Aggressive Portfolio Class R6 JPMorgan Intrepid Sustainable Equity Fund I Class JPMorgan International Advantage Fund Class R2 JHF International Dynamic Growth Fund Class A JHF International Dynamic Growth Fund Class C JHF International Dynamic Growth Fund Class I JHF International Dynamic Growth Fund Class R6 JPMorgan SmartRetirement Blend Income Fund I Class John Hancock Funds II Multimanager Lifestyle Aggressive Portfolio Class 1 John Hancock Funds II Multimanager Lifestyle Balanced Portfolio Class 1 John Hancock Funds II Multimanager Lifestyle Conservative Portfolio Class 1 John Hancock Funds II Multimanager Lifestyle Growth Portfolio Class 1 John Hancock Funds II Multimanager Lifestyle Moderate Portfolio Class 1 JPMorgan Inflation Managed Bond Fund A JPMorgan Inflation Managed Bond Fund C Johnson Institutional Short Duration Bond Fund Class F Johnson Institutional Intermediate Bond Fund Class F Johnson Institutional Core Bond Fund Class F JPMorgan Short-Intermediate Municipal Bond Fund I Class JPMorgan Inflation Managed Bond Fund R6 JPMorgan Inflation Managed Bond Fund R5 John Hancock Funds II Mid Cap Stock Fund Class 1 JPMorgan Prime Money Market Fund IM JPMorgan Multi-Sector Income Fund Class C Johnson International Fund JPMorgan Prime Money Market Fund - Institutional Share Class JPMorgan SmartRetirement Blend 2020 Fd R2 John Hancock Fds II Strategic Income Opportunities Fd Class A John Hancock Fds II Strategic Income Opportunities Fd Class C John Hancock Fds II Strategic Income Opportunities Fd Class I John Hancock Funds II Strategic Income Opportunities Fd Cl R2 John Hancock Funds II Strategic Income Opportunities Fd Cl R6 JPMorgan SmartRetirement Blend Income Fd R2 John Hancock Funds II Real Estate Securities Fund Class 1 John Hancock Funds II International Small Company Fd Cl A Janus Henderson Small Cap Value Fund - S Shares John Hancock Funds II International Small Company Fund Class C JPMorgan Small Cap Growth Fund Class L JPMorgan International Advantage Fund Class I John Hancock Funds II Small Cap Opportunities Fund Class 1 JPMorgan Multi-Sector Income Fund R2 JPMorgan Intermediate Tax Free Bond Fund A JPMorgan Intermediate Tax Free Bond Fund C JPMorgan Intermediate Tax Free Bond Fund I Class JPMorgan SmartRetirement Blend Income Fund - R4 JPMorgan SmartRetirement Blend Income Fund - R3 JPMorgan Intermediate Tax Free Bond Fund Class R6 JPMorgan International Value Class C JPMorgan Intrepid Value Fund Class A JPMorgan Intrepid Value Fund Class C International Value Portfolio C2 International Value Portfolio A John Hancock Funds II International Value Fund Class 1 JPMorgan Intrepid Value Fund R6 JPMorgan Intrepid Value R5 JPMorgan Intrepid Value Fund R2 JPMorgan SmartRetirement Blend Income Fd R6 Capital Appreciation Portfolio A Capital Appreciation Portfolio C2 John Hancock Funds II Multimanager 2060 Lifetime Portfolio Class A John Hancock Funds II Multi-Index 2060 Preservation Portfolio Class R1 John Hancock Funds II Multimanager 2010 Lifetime Portfolio Class A John Hancock Funds II Multimanager 2010 Lifetime Portfolio Class R1 John Hancock Funds II Multimanager 2010 Lifetime Portfolio Class R2 John Hancock Funds II Multimanager 2010 Lifetime Portfolio Class R3 John Hancock Funds II Multimanager 2010 Lifetime Portfolio Class R4 John Hancock Funds II Multimanager 2010 Lifetime Portfolio Class R5 John Hancock Funds II Multimanager 2010 Lifetime Portfolio Class R6 John Hancock Funds II Multimanager 2010 Lifetime Portfolio Class 1 John Hancock Funds II Multimanager 2015 Lifetime Portfolio Class A John Hancock Funds II Multimanager 2015 Lifetime Portfolio Class R1 John Hancock Freedom 529 Multimanager Lifestyle Balanced 529 Portfolio Class A John Hancock Funds II Multimanager 2015 Lifetime Portfolio Class R3 John Hancock Funds II Multimanager 2015 Lifetime Portfolio Class R4 John Hancock Funds II Multimanager 2015 Lifetime Portfolio Class R5 John Hancock Freedom 529 Multimanager Lifestyle Balanced 529 Portfolio Class C2 John Hancock Funds II Multimanager 2015 Lifetime Portfolio Class R6 John Hancock Funds II Multimanager 2015 Lifetime Portfolio Class R2 John Hancock Funds II Multimanager 2015 Lifetime Portfolio Class 1 JPmorgan U.S

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Kaess BM, Preis SR, Lieb W, Beiser AS, Yang Q, Chen TC, Hengstenberg C, Erdmann J, Schunkert H, Seshadri S, Vasan RS, CardioGram ATL, Deloukas P, Holm H, Kathiresan S, Konig IR, McPherson R, Reilly MP, Roberts R, Samani NJ, Stewart AF (2015) Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community