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Tirzepatide has a roughly 5-day half-life, so there will still be residual drug in your system when you begin sublingual dosing

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The mechanisms involved in the beneficial actions of GLP-1 receptor agonists on MASLD are indirect, given the virtual absence of GLP-1R in hepatocytes, except for those in T cells which are associated with anti-inflammatory effect.9 These include fat mass reduction, increased hepatic insulin sensitivity, reduced tissue lipotoxicity, anti-inflammatory effect and improved mitochondrial function32 (Fig