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Regarding mechanism linkage and integration, research further reveals that the two most common OA pathogenic stimulichronic inflammatory cytokines such as IL-1 and abnormal mechanical stresscan effectively induce ferroptosis in chondrocytes

Nox enzyme-dependent NET formation is well-characterized, involving increased ROS production, neutrophil granule and nuclear membrane disintegration, and the release of neutrophil elastase (NE) and myeloperoxidase (MPO) (95)

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