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When tirzepatide is injected into subcutaneous tissue, the immune system may recognize the medication or the injection process as a minor insult, triggering the release of inflammatory mediators such as histamine and cytokines

For ASCs that fail to meet their quality reporting requirements, the CY 2026 payment determinations would be based on the application of a 2.0 percentage point reduction to the hospital market basket update for CY 2026