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Acknowledgments The authors thank professor Haibo Mu who provided helpful comments for revising the paper

In general, the instability of Env spikes is reflected in the strong antibody responses often observed to post-fusion conformations of Env in many viral infections

It has been shown that tryptophan metabolism is enhanced in COVID-19 infection, leading to a decrease in tryptophan and increased levels of kynurenine metabolites (43), which can have multiple deleterious effects on the musculoskeletal system (70)

This section moves beyond a deterministic view of SFN bioavailability to focus on the host factorsspecifically the gut microbiome and host geneticsthat act as key determinants of efficacy