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10.1016/j.bpobgyn.2018 24

Program in Sciences and Innovation in Medicine at Universidad del Desarrollo The PIKfyve-ULK1 Axis: Coordinating Lysosomal Membrane Repair and Mitochondrial Bioenergetics Disruption of the PIKfyve/Fig4/Vac14 complexand the subsequent depletion of PI(3,5)Ptriggers a multifaceted compensatory stress response that couples lysosomal proteostasis with mitochondrial bioenergetics