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Superoxide (O 2 ) is produced by one electron reduction of oxygen by different oxidases including dihydro nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, xanthine oxidase, cycloxygenase as well as by the mitochondrial electron transport chain during the course of normal oxidative phosphorylation which is essential for generating ATP (Evans et al ., 2003) (Fig

Antibiotic-induced biofilm formations in pseudomonas aeruginosa strains kpw.1-s1 and hrw.1-s3 are associated with increased production of eDNA and exoproteins, increased ROS generation, and increased cell surface hydrophobicity

Conclusive evidence may be forthcoming

It results from a combination of increased sebum production by sebaceous glands and hyperkeratinization, with a known role for transcription factor GATA6 deregulation in its pathogenesis [33]