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Caspase activation was measured using ApoTox-Glo triplex assay reagent according to the manufacturers recommendation

*Correspondence: Claudia Mandato [email protected] Present address: Anna Pia Delli Bovi, Residency Program in Pediatrics, University of Siena, Siena, Italy This article was submitted to Gastroenterology, a section of the journal Frontiers in Medicine These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Typically, hepatocellular carcinoma (HCC) is detected at a late stage, which significantly worsens the prognosis