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It activates the mitochondrial stress response in adipocytes [108]

In comparison to eukaryotes, studies have shown that most of the residues that are highly conserved in theta and other bacterial class GSTs are not retained in those of the alpha, mu, and pi classes of eukaryotic GSTs

Considering the positive impact of Nrf2 in ameliorating oxidative stress, a number of bioactive components that exert protective effect against APAP-associated hepatotoxicity have been identified and reported, including caffeic acid that activates the Keap1-Nrf2 antioxidant defense system (Pang et al., 2016), carnosic acid that promotes nuclear translocation of Nrf2 (Guo et al., 2016), and esculentoside A that activates Nrf2 via AMP-activated kinase/Akt/glycogen synthase kinase 3 pathway (Wang et al., 2016)

Colocalization with automatic thresholding (ImageJ/Fiji, v1.53t, NIH) is based on a pixel-by-pixel measure of the Pearson correlation of intensities after automatic subtraction of pixels with zero correlation