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In addition to commonly used iron chelating therapy, regulating hepcidin levels may also help alleviate iron overload in -thalassemia patients, due to their typically low hepcidin levels

In ovarian cancer, tumor-released mesothelin, which is linked to a glycosylphosphatidylinositol (GPI) anchor, binds to MR on macrophages, driving their polarization toward the TAM phenotype, which supports tumor growth and suppresses the immune response

Cuadrado A, Manda G, Hassan A, Alcaraz MJ, Barbas C, Daiber A, et al

Single-cell transcriptomic and lineage-tracing analyses suggest that resident macrophages mainly contribute to TAM pools within omental metastases and milky spots, whereas monocyte-derived macrophages dominate in ascites [20,73]