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MOTS-c : also zero, on the specific question of a large published human trial proving fat loss or metabolic benefit from supplementation

A large 24-week trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo when combined with diet and exercise

The simplest way to explain it: Tesamorelin is the stronger abdominal-fat peptide

Some clinics pivoted to recommending FDA-approved alternatives for weight management, including GLP-1 receptor agonists such as semaglutide (Wegovy) and tirzepatide (Zepbound), both of which have extensive Phase III data and FDA-approved labels