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Functional/Acquired IGF-I Deficiency - Uncoupling of GHR Signaling to IGF1 Gene Transcription and Maintained GHR Metabolic Signaling Due to Insulin Deficiency Increased GHR signaling in obese children does not generally result in elevated IGF-I, due to negative feedback inhibition of GH

These responses have mutual effects, and it is difficult to determine the dominant pathways

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When you introduce a compound into a cell culture or biochemical assay, any impurity becomes an uncontrolled variable