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Interaction between Metformin, Folate and Vitamin B12 and the Potential Impact on Fetal Growth and Long Term Metabolic Health in Diabetic Pregnancies Metformin & Vitamin B12 Deficiency: Why It Happens? In a patient taking metformin 1000 mg twice daily who has vitamin B12 deficiency, how long should vitamin B12 supplementation be continued? Metformin, one of the most frequently used medications to manage patients with diabetes, can impact the absorption of vitamin B12. A patient on Metformin with worsening neuropathy should be screened for a
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