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Narcotic addiction, physical dependence and relapse

Maintaining proper magnesium balance is essential for numerous physiological processes in the body

Furthermore, -syn exacerbates mitochondrial dysfunction by binding to VDAC, where it partially obstructs the pore and thereby impairs the transport of ATP/ADP and other metabolites

Notably, in these studies, the upregulation of GPx4 has been achieved by using exogenous agents (like NVP-AUY922, Bafilomycin A1, PD151746, GsMTx4, epigallocatechin-3-gallate, total flavonoids of Engelhardia roxburghiana leaves, Lycium barbarum polysaccharide-glycoprotein, perillaldehyde, melotonin, ferulic acid, and sphingosine-1-phosphate) which either inhibit the degradation of GPx4 or increase its transcription by activating the Nrf2 [67]