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More significantly, these comprehensive analyses that generate metabolic profiles represent not only biomarkers for disease but also metabolic maps that can be used to identify specific genes responsible for disease

ASN Neuro 4 , e00093 (2012)

While the aim of this article is not to review these and other considerations in detail, the box below represents a compilation of a few unanswered questions that could guide further academic and clinical discourse in this area

The strong enrichment of amino acid biosynthesis (vra01230) and related pathways, viz., alanine, aspartate and glutamate metabolism (vra00250), arginine biosynthesis (vra00220), glycine, serine and threonine metabolism (vra00260), and cysteine and methionine metabolism (vra00270), indicates an adaptive accumulation of osmoprotective and stress-responsive amino acids