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doi: 10.1016/j.abb.2023.109870 116 SusukiKZollingerDRChangK-JZhangCHuangCY-MTsaiC-Ret al

Accumulating evidence suggests that NAD + levels decline with age in a variety of organisms, including humans and rodents, resulting in age-related pathophysiological changes [3,4,5,6,7] and disorders, such as cognitive decline, cancer, metabolic diseases, sarcopenia, and frailty [2]