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It has been shown that extracts derived from unfermented cocoa, green tea, and red grape seeds that include a high polyphenol concentration are effective against Streptococcus mutants and periodontal disorders

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But doing it too much for the whitening effects, like once every two-three days, problems can arise in renal functioning, or even put pressure on your nervous system. According to the World Health Organization, there are no universally accepted dosage guidelines

Moldogazieva N, Mokhosoev I, Feldman N, Lutsenko S (2018) ROS and RNS signalling: adaptive redox switches through oxidative/nitrosative protein modifications