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The voluminous research on the compounds listed above is notable not just for the establishment of the depth and breadth of the signaling pathways they disrupt, but for the coincident research demonstrating that most of these same compounds cause the death (apoptosis) of pancreatic cancer cells, inhibit the growth of pancreatic tumors in animal models, and reduce the resistance of pancreatic cancer cells and tumors to standard chemotherapy drugs - agents to which these cells and tumors are, normally, without bio-modulation, sorrowfully ineffective

As a result, more recent studies have led researchers to recommend B complex supplementation in those utilizing L-DOPA therapy

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It is usually caused by problems in the inner ear or central nervous system