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mtDNA proximity to these ROS production sites makes them more vulnerable to damage, mutations, deletions, and genetic instability [16]

doi:10.1113/expphysiol.2004.029462 48

[A prospective study of adenosine triphosphate-tumor chemosensitivity assay directed chemotherapy in patients with recurrent ovarian cancer]

While both the classic and trans-signaling receptor complexes activate similar intracellular signaling pathways, emerging evidence suggests that classic signaling is essential for the anti-inflammatory and regenerative effects of IL-6, whereas IL-6 trans-signaling tends to promote pro-inflammatory responses