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10.2169/internalmedicine.49.3509 23 GanJ.HarperT

Antioxidants are substances that can eliminate and neutralize FRs within the body and free the body from the oxidative stress that occurs due to the accumulation of FRs

Zhou J, Johnson JE, Ghetie V, Ober RJ, Ward ES

Collectively, these changes translate into a more pronounced improvement in mucosal barrier repair than that achieved with 5-ASA alone ( The combination of natural bioactive compounds with 5-ASA offers a novel therapeutic strategy for ulcerative colitis through a stage-specific, multi-target synergistic approach.These complementary mechanismsspanning acute immunomodulation, antioxidative damage, followed by active mucosal repair, and microbiota-metabolic regulationare visually integrated in Figure 2, which provides a comprehensive overview of their temporally coordinated actions