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The incidence and risk of acute renal failure after cardiac surgery

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Network pharmacological studies revealed that QSHWC contains 35 major active ingredients that can reduce the cardiotoxicity of anthracyclines by regulating PI3K/Akt, MAPK, FOXO, and other signaling pathways to regulate cellular autophagy and reduce the cardiotoxicity of anthracyclines (135), QSHWC downregulated pirarubicin-induced LC3, and played a cardioprotective role by inducing PI3K, AKT, and mTOR phosphorylation and pathway activation (136)