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The results of immunostaining and western blot showed that an obvious increased protein expression of 4-HNE was found in peroxynitrite treated SGNs, while it was significantly decreased in peroxynitrite + ebselen group but further increased in peroxynitrite + gpx1 / mice compared with the peroxynitrite-only group (Figures 5B,C)

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Alternatively, the controversial results may be explained by the in vitro determined key elements of stress protection being not necessarily important in vivo, or by the stress developing in vivo in an immunocompromised host being not necessarily restrictive enough to prevent infection [29,30,31]

The mechanism might involve direct antiemetic effects of B12, or it might reflect improved overall metabolic function when vitamin status is maintained