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doi: 10.1093/jn/138.10.2045S

These neuroprotective effects appear mediated through enhanced cellular autophagy via TFEB nuclear translocation (Lai et al., 2022)

Unlike its parent molecule EPO, ARA-290 selectively activates tissue repair mechanisms without stimulating erythropoiesis, offering a potentially safer therapeutic profile

Detoxification enzymes of phase II compete with the activating enzymes of phase I to restrict the generation of electrophiles and catalyze the conversion of these electrophilic molecules to inactivate conjugates, making them more soluble in water and more easily get excreted from the body