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Importantly, ABT-737 demonstrates proven senolytic properties against cancer cells

2A, under 660 nm laser irradiation, the prodrug generates ROS, which not only effectively enhances the photodynamic therapy efficacy but also controls the release of CPT from the prodrug, thereby improving chemophotodynamic cancer therapy(Table 2)

Nevertheless, a recent population study has highlighted that NASH patients have a higher incidence of fatigue and abdominal discomfort which are shown to be correlated with hepatic lobular inflammation (Huber et al., 2019)

Common mechanisms (HDAC inhibition, AhR activation, TLR signaling) integrate metabolite-specific effects, resolving the patchwork criticism