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A single process underlying different hyperglycemia-induced pathogenic mechanisms: mitochondrial superoxide production Specific inhibitors of aldose-reductase activity, AGE formation, RAGE ligand binding, PKC activation and hexosamine pathway flux each ameliorate various diabetes-induced abnormalities in cell culture or animal models, but it has not been clear whether these processes are interconnected or might have a common cause [99,131134]

As the available models do not accurately model the structure or filtration function of the glomerulus, their applications are limited

Other thyroid disruptors broadly described in the literature are polychlorinated biphenyls, polybrominated diphenyl ethers, pesticides, phthalates, and perfluoroalkyl substances [9, 24, 25]

It can no longer act as an antioxidant until it is "recharged" or recycled back into its reduced form