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76 Also, with some Class I variants the oxidation of membrane sulfhydryl groups leads to the accumulation of membrane polypeptide aggregates, presumably due to disulfide bond formation between spectrin dimers and other membrane proteins

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The ROS scavenging property of Sp was also replicated in the Drosophila models knocked-down for essential antioxidant enzymes catalase and glutathione peroxidase, where neuronal cells of 15 days AEL flies genetically expressing a redox biosensor, roGFP showed reduced fluorescence under Sp treatment (Fig

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