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In recent years, new studies have proposed various therapeutic targets or approaches for the treatment of noise-induced hearing loss, e.g., epidermal growth factor inhibitors have shown promising efficacy in mouse and zebrafish models, superparamagnetic iron oxide nanoparticle assembly (SPIOCA) can remodel gut dysbiosis to treat noisy hearing loss, and nicotinamide encapsulated by personalized porous gelatin methacrylamide can effectively enhance drug delivery efficiency to treat noisy hearing loss

Comparing the former version of these documents and the 2026 updated ones, the major changes are: Further examples or clarifications have been added to the following substance classes to help athletes and their entourage better identify prohibited substances: S1

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