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Thus, future research should focus on developing diagnostic models based on genetic variations to predict HAPE susceptibility as accurately as possible

4.5 Oxidative stress and cellular senescence High lactate concentrations can accelerate tissue degeneration through various molecular mechanisms

JAMA 320: 969970 Jackson SH, Devadas S, Kwon J, Pinto LA, Williams MS (2004) T cells express a phagocytetype NADPH oxidase that is activated after T cell receptor stimulation

The RCTs reviewed in the meta-analyses included in this work were routinely reported as having significant heterogeneity, low to moderate methodologies, and high risk of bias, including poor blinding of investigators and subjects, analytical methods, and poor control of confounding factors