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This dormant state can be activated by specific stimulielevated glutathione (GSH), enzymatic action, or lightenabling precise spatiotemporal control over the release process (Fig

Homoeostatic systems associated with astrocytes in healthy tissue also support neuroprotection after insults, for example by supplying neurones with energy substrates in ischaemic conditions, scavenging reactive oxygen species (astroglia are the main source of glutathione), removing excess glutamate and buffering K + ions, thus containing excitotoxicity, and actively taking up or detoxifying various toxic agents

DOI: 10.3390/pharmaceutics14122686