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After three months of cyclic senescent cell removal using D+Q, we assessed cerebral blood flow, brain volume and ventricle volume with MRI to determine if removing senescent cells produced global effects on brain function and structure

From a translational perspective, a recent study found a positive correlation of TREM2 expression levels in AT with BMI only in males and between a specific TREM2 polymorphism and BMI in female individuals 57

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This is particularly important since BRAF V600E expression in Ink4a/Arf-deleted cells has been shown to increase the proportion of proliferative glial progenitor cells in adult mice in vivo , disrupt asymmetric cell division of OPCs, and increase OPC frequency in vitro at the expense of mature oligodendrocytes and astrocytes, respectively, without altering NSC frequency ( V600E expression and Ink4a/Arf loss than NSCs